Events leading to the developement of Gerovital GH/VITACEL products
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Will it Bring Back the Young in Us?
There is a vitamin product that has been available in the United States for many years that has proven to be effective in many cases against degenerative diseases. Developed by Dr. Ana Aslan, Director of the Bucharest Institute of Geriatrics and Gerontology in Romania. Her research and clinical tests showed it helped people with the following problems as well as many others.
•Arthritis •Hypertension •Senility •Heart
disease •Poor hearing •Parkinson's disease
•Cholesterol •Multiple sclerosis •Ulcers
•Stress •High blood pressure •Angina
•Pectoris •Low blood pressure •Arteriosclerosis
•Impotency •Muscular fatigue •Frigidity
•Depression •Crohn's disease •Varicose veins
•Balding •Poor circulation •Allergies
The product is Gerovital H-3 (GH-3) - Vitacel 3
Why is it that thousands of Americans and others have been making an
expensive pilgrimage to Romania every year? The answer: GH-3 treatments. Why did many famous people such as the Gabor
sisters, Marlene Dietrich, Charlie Chaplin, Lillian Gish, John F. Kennedy, Lena Horne, Dick Clark and many others travel
so far to receive these treatments? The reason is that Dr. Ana Aslan proclaimed GH-3 had been proven to have rejuvenative
effects at the cellular level and was effective in the fight against degenerative diseases. Her research has been
documented for 40 years and shows many thousands of case histories of relief from just about every type of disease
associated with aging.
The Romanian government dispenses GH-3 regularly to its population
that is middle-aged and older. Over 200,000 people have received injections or tablets from the Institute, with less
than one in six thousand having any allergic reaction. There is no limit on age, The oldest patient came to Dr.
Aslan when he was 106. He lived ten years more, in a much better condition than when he first came to the Institute,
as a result of treatment with GH-3.
GH-3 has become the subject of increasing medical research and recognition around the world during the last quarter century and it was the subject of a best-selling book "GH-3 Will it Keep You Young Longer?" by Herbert Bailey, which sold over one million copies in the U.S. alone. Numerous clinical studies in the U.S. and elsewhere have established the following beneficial properties for GH-3: (1) GH-3 is a potent anti-depressant and brain tonic, most users become significantly more alert and cheerful; (2) GH-3 often arrests such aging symptoms as hair loss, greying, wrinkling and hardened skin; (3) Users of GH-3 have reported dramatic improvements for a great variety of seemingly unrelated problems. These reports are common enough to merit scientific recognition but they are variable and unpredictable.
The Fountain of Youth
Gerovital H-3 has been called the fountain of youth, the miracle anti-aging vitamin product, the total rejuvenator. These claims are exaggerated but GH-3 has shown itself to be helpful in these areas. It is actually a very simple combination of two B-vitamins, PABA (p- aminobenzoic acid) and DEAE (diethylaminoethanol) buffered and stabilized with benzoic acid and potassium metabisulfite for more effectiveness inside the body. The combination of PABA and DEAE is a compound called procaine hydrochloride, a vitaminic substance first synthesized in 1905 by a German chemist, Dr. Albert Einhorn, who was looking for a simple, non-addictive anesthetic. Today procaine is approved by the FDA and used throughout the United States under the trade name of Novocaine.
The Miracle Begins
For years procaine was used as a simple anesthetic, but soon researchers began to notice other curative powers of this substance. Interest in experimentation ran so high that between 1930 and1951 over 165 reports were published on the effects of procaine in the treatment of a variety of conditions including arthritis, neuralgia, itching, peptic ulcer, asthma and hypertension. In the late 1940's three French physicians Drs. Ghali, Boudon, and Guoit - found that procaine hydrochloride helped relieve suffering from asthma attacks. Dr. Rene Leriche discovered that procaine injections were helpful in treating certain forms of arthritis, arteritis and blood clots in the limbs.
PABA and DEAE
Once in the body, procaine breaks down into the B vitamin PABA and DEAE which is converted to the B vitamin Choline in the cells of the body. By itself PABA works mostly in the glands, hair, intestines and aids the body in blood cell formation, protein metabolism and skin functions. Studies have shown that a PABA deficiency can cause constipation, depression, digestive disorders, stress, infertility, fatigue, gray hair, headaches, and irritability. Its function is to stimulate the intestinal bacterial system to produce other B vitamins such as folic acid, pantothenic acid, biotin, as well as, vitamin K. Ingesting PABA alone may not always get results because it is rapidly disposed of by the liver when in the free form. When nestled in the procaine hydrochloride molecule, PABA becomes more effective.
The other part of the procaine molecule - DEAE - has been shown to have a definite anti-depressant effect. Double blind studies by Carl Pfeiffer, Head of the Brain Bio Center at Princeton, showed that DEAE produces mental stimulation and mild euphoria, with no toxic side effects. DEAE also is a precursor of two body substances most important to the central nervous system, choline and acetylcholine. Both are known to be basic to the bodies stress reaction system. DEAE also provides raw material for the production of cell membranes inner and outer layer phospholipids.
The eminent medical researcher Dr. Ana Aslan, first noticed the rejuvenative effects of procaine in her work at the Institute of Geriatrics in Bucharest, where she was first appointed as Director in 1949. Dr. Aslan was able to duplicate the work of Leriche and began to study procaines effect on arthritis. Between 1949 and 1951, Aslan conducted animal studies and found that procaine injections yielded complete cures in 85 percent of the laboratory rats that had artificially induced arthritis. Her first clinical tests produced the same results. Dr. Aslan noticed that other afflictions rapidly improved in her group of patients. Afflictions that could not be helped by traditional methods. There was an improvement in memory, a decrease in morbidity due to Parkinson's disease and an increase in muscular power. The psychological effects were also interesting. Patients seemed to be more involved in life.
Intrigued by these discoveries Dr. Aslan also began to improve upon the basic procaine hydrochloride. She buffered and stabilized until she came up with a far superior and much more effective compound which she called Gerovital H3 or GH-3.
Improvements and Test Results
With the perfected GH-3, Dr. Aslan began ambitious experiments involving twenty five patients in a three year study. That year, 1951, the entire Geriatric Institute was turned over to Dr. Aslan - a great vote of confidence for her research. Three years later, in 1954 she reported her findings in the Journal of the Romanian Academy of Science. Patients showed greater vitality and improvements in specific diseases when treated with GH-3.
In 1956, at the Karlsruhe Therapy Congress meeting in Germany, Dr. Aslan presented the following final results; studies with three groups of patients living at the Institute, each group containing thirty to forty patients and 2,500 out-patients, showed that they were benefited greatly by the use of GH-3. Dr. Aslan claimed that GH-3 relieved depression, hypertension, arthritis and angina pectoris as well as producing muscular vigor and had a "regenerative effect at the cellular level."
These results were confirmed in several Romanian studies the largest of which took place in 1970, when Dr. Aslan set up one of the most carefully planned scientific experiments ever. For two years, 15,000 people from the ages of forty to sixty two were tested at 144 centers throughout the country. Although patients had all sorts of jobs, both the control and treated groups received strict medical attention including vitamin therapy. The GH-3 treated patients showed a significantly higher degree of improvement.
Dr. Alfred Sapse
Alfred Sapse had interned as a young doctor in Romania and had seen some of the seemingly miraculous results Dr. Aslan had with GH-3. Said Sapse of the old people who were treated, "Their ailments were either gone or greatly regressed, at least to the point where they didn't bother these old people. I saw these people before and after treatment and I know what I saw. It was incredible to me. I never forgot it."
Obsessed with his memories of GH-3, Sapse followed studies of GH-3 and the aging process, through the years, from his position as assistant professor in the department of immunology at UCLA in the early 70's. A team of researchers at the National Institute of Mental Health came up with some definitive answers as to why depression occurs among the elderly, which interested Sapse. The NIMH team had shown that depression was caused by a buildup of the enzyme monoamine oxidase (MAO) in the brain. This was found to occur around age forty five and to continue with age. The search was on for a product that could inhibit this buildup without destroying the natural usefulness of MAO in the body.
Sapse built his case on research that went back to 1940 -American studies such as that of Dr. J.F. Philpot, who discovered that procaine was a MAO inhibitor in the test tube. Back then nobody knew what significance MAO had. As soon as the NIMH studies came out, Philpot's discovery took on added meaning and his results were soon confirmed in Italy. Sapse took all these clues and worked night after night on a computer to come up with the basis for a full-scale U.S. inquiry into GH-3.
Studies in the U.S.A.
Dr. Sapse gathered together some top scientists for a battery of tests on GH-3 that would, he hoped, end in FDA approval of its distribution in the United States. His group acquired exclusive rights for distribution from the Romanian government, received an investigative drug number from the FDA and then moved into action. Their quest- to prove that GH-3 was a safe and effective anti-depressant for the elderly.
The first study confirmed that GH-3 was indeed a MAO inhibitor. This test also showed GH-3 to be a weak and reversible inhibitor that does no permanent damage to the MAO system. No other anti-depressant was found to do this. Next it was shown that GH-3 gave "prompt and dramatic" improvement in depression and insomnia patients already under psychiatric care. The patients were also found to have a general improved sense of well being as a result of the treatment. In addition, those patients with high cholesterol levels were found to have reduced serum cholesterol after only four weeks of treatment.
Double Blind Studies
Phase two of the exhaustive GH-3 investigation consisted of double blind studies in which the GH-3 would be tested against a placebo with neither the doctor nor patient knowing which group received the real GH-3 until the end of the study. The Kurland and Hayman double-blind report at UCLA confirmed GH-3 to be more effective than a placebo with no side effects in sixty four older patients with depressive conditions.
In addition to the first study, another test conducted by Duke University's eminent researcher-psychiatrist William Zung, was actually a triple-blind test because it included a group that received the drug imipramine, a known and approved remedy for depression. At the end of the experiment GH-3 proved to be superior to both the placebo and the imipramine drug.
The final part of the investigation consisted of GH-3 being tested by twenty to thirty psychiatrists all over the country. This was mainly to confirm the efficacy of GH-3 on a larger scale and determine if there was an allergic response.
After three years of study, the incredibly sound and positive case for GH-3 had been made. Sapse was confident that GH-3 would soon gain FDA approval as an effective and safe anti-depressant, among other important uses, and would soon be able to alleviate the suffering and depression of people in the U.S.
Politics and Confusion in the U.S.A.
Ironically, it is in the place where the best and most illuminating research was conducted - America - that the mire of politics and confusion would overcome the use of GH-3 and make it impossible for further research to be conducted.
With the cooperation of the Romanian government and a wealth of scientific testing to back him up, Dr. Alfred Sapse was set to market GH-3 as an anti-depressant upon FDA approval.
At the time however, a tremendous amount of publicity came to bear about GH-3 as an anti-aging substance. Although GH-3 had been tested throughout the world for the safety of its rejuvenative properties, the FDA felt that not enough research had been done in the U.S. to prove that GH-3 was indeed useful against aging. The FDA therefore demanded that Sapse prove that GH-3 was also effective against aging.
Sapse appealed this decision which would have taken millions of dollars and many years of further research to prove. In 1976 the FDA agreed to the appeal. Wrote Ross S. Laderman, chief of the Advisory Opinions Branch at the Bureau of Drugs Division of the FDA. "This decision was based on our feeling that there was no evidence that Sapse was responsible for the extravagant publicity surrounding Gerovital and it would be unreasonable for the agency to require that the extravagant claims be tested."
However, when Sapse once again tried for approval the FDA stated that Sapse should test the GH-3 with a younger population as well as geriatrics. With this decision Sapse could no longer continue financially. The additional studies to fulfill the unreasonable expectations of the FDA were estimated to cost many millions of dollars and at least a decade of additional time.
Is the FDA's refusal to approve the use of GH-3 based on anything more than economical and political wishes? Who are they protecting, certainly not the American people.
What Happened to Dr. Ana Aslan?
Dr. Aslan was a spry energetic lady who worked six days a week, 12 hours a day, until she died at 91 years of age. She directed the Institute of Geriatrics and Gerontology in Romania. She traveled all over the world lecturing on how to control the aging process right up until her death in the spring of 1988. She often spoke of her outlook on aging, as one who was ranked with the elderly. "Eventually we all die," she said to a group, "but with GH-3 we can die healthier. Aging is like a disease some times you can heal it. Life can be prolonged and more importantly, these years can be filled with vitality and the joy of life."
Dr. Aslan always wished the United States would take up her work. This is happening now. Vitacel 7, also known as GH-7, is the development from the research of a scientist Dr. Robert Koch, a biochemist from Salt Lake City, Utah. Dr. Koch, learning of Dr. Ana Aslan's research in 1981, was so impressed with her work that he decided to research GH-3 and what he calls, procaine based nutriments (PBNs). Dr. Koch believes that aging is a natural process that isn't necessarily associated with disease. "People should grow old and die because they are old not because they are sick." "The degenerative diseases that afflict us are Life Style Diseases not diseases of aging."
GH 7 has vitaminic complexing agents that keep the procaine hydrochloride working for many hours in the body. These replace the bisulfite and benzoic acid which Dr. Aslan used in GH-3. GH 7 has the same procaine hydrochloride content as GH-3, which seems so effective in accelerating improved feeding of damaged and diseased cells. Former users of GH-3, who are now using GH 7 testify as to its increased effectiveness.
Have the Results Been Duplicated in North America?
Yes! In fact the success statements have been so numerous that for almost any condition there is a basis of reference, often an address and phone number where you can reach the person with the story.
Keep in mind that GH 7 is not sold as a cure for anything. It helps body cells take in nourishment better and get rid of waste more efficiently. This gives the cells a fighting chance for survival against the many enemies around them every day. The fact that so many people are excited about what has happened to them is witness to the body's ability to cope with health hazards that steadily and consistently attack it.